Mechanism Action Therapeutic Use Olazanpine Ariprpazole Treatment Schizophrenia Biology Essay Essay Example

Mechanism Action Therapeutic Use Olazanpine Ariprpazole Treatment Schizophrenia Biology Essay Essay In pharmacological medicine, drug is a substance used for the bar, diagnosing, remedy and intervention of disease and for the alleviation of symptoms. It could besides heighten physical or mental wellbeing. There are many mental upsets, a province in which an person s mental orientation is disrupted.A Examples of mental upsets include ; A Acute passion, bipolar, schizophrenic disorder, depression, For this peculiar essay I will be speaking about schizophrenic disorder, its symptoms, proposed aetiology and illustrations of the 2nd coevals drug therapies being used to pull off the status. We will write a custom essay sample on Mechanism Action Therapeutic Use Olazanpine Ariprpazole Treatment Schizophrenia Biology Essay specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Mechanism Action Therapeutic Use Olazanpine Ariprpazole Treatment Schizophrenia Biology Essay specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Mechanism Action Therapeutic Use Olazanpine Ariprpazole Treatment Schizophrenia Biology Essay specifically for you FOR ONLY $16.38 $13.9/page Hire Writer Schizophrenia is a aggregation of symptoms characterised by idea upsets reflecting a interruption between the cognitive and emotional sides of one s personalityA ( Kathryn L. McCance, 2010 ) .A Schizophrenia is classified into positive and negative symptoms utilizing two systems, viz. ; ICD-10 and DSM-IV ( Horton, Schizophrenia, 2011 ) . Positive symptoms which are unnatural experiences non experienced by other people include Hallucination: Described as a perceptual experience experienced in absence of an external stimulation and characterized largely as auditory with patients proposing that they hear voices speaking to them, about them, commanding them, noticing or an reverberation of their ideas Delusion: False belief that they are under the control of an external influence or their ideas are known to other people i.e. paranoia of the wireless or Television FORMAL THOUGHT DISORDER: A upset of conceptual thought reflecting trouble to understand address and rapid displacement from a subject of capable to another i.e. deficiency of consciousness. New words are besides invented ( neologies ) A ( Horton, Schizophrenia, 2011, pp. 1-2 ) Negative symptoms are normal experiences which are non experienced by schizophrenic patients which include ; SOCIAL WITHDRAWAL/ANHEDONIA: proposing they isolate themselves from the universe LACK OF MOTIVATION: deficiency of involvement in things that antecedently interested them Blunted Consequence: Inability to respond usually to emotional stimulation e.g. when informed of the decease of person they laugh alternatively of sympathising A INSIGHT: schizophrenic disorder patients do non belief anything is incorrect with them or the demand for intervention Nether Activity: Do less and speak less than usually COGNETIVE Deficits: Deficits in attending, memory and job resolution ( Horton, Schizophrenia, 2011, p. 2 ) Epidemiology: An incidence rate of 25 per 100,000 per twelvemonth with Life risk 1 % , common in both sexes but onset earlier in work forces [ average age 28years ] whilst adult females [ 32years ] , common in lower socio-economic groups and urban countries ( Horton, Schizophrenia, 2011, p. 2 ) . Familial epidemiologic surveies indicate it is a heritable upset. Lifetime event hazard indicates 8-10 % for siblings with schizophrenic disorder, one parent with schizophrenia 12-15 % whist with both parents ~40 % . In monozygotic twins the harmony rate was 60 % compared to 10 % in dizygoticA twins and Adoption surveies illustrate that cistrons are more critical compared to environment ( Horton, Schizophrenia, 2011, p. 4 ) . However, it differs from simple familial and Mendelian upsets because it involved several cistrons located on different chromosomesA ( Kathryn L. McCance, 2010 ) .A Therefore, no individual cistron has a major consequence but they include 8p, 13q and 22q ( Horton, Schizophrenia, 2011, p. 4 ) . Pathological surveies have observed the undermentioned grounds in the encephalon of schizophrenic patients and they include hypertrophied ventricles ( ~ 40 % ) , reduced encephalon weight ( ~ 30 % ) , reduced cortical Grey affair ( ~ 4 % ) , unnatural bunch of neurones in the cerebral mantle, little cell organic structures and decreased basal dendrites ( Horton, Schizophrenia, 2011, p. 4 ) . CHEMICAL/ NEUROTRANSMITTER THEORY A DOPAMINE THEORY: Hypothesized as due to over activity of Dopastat in the mesolimbic-mesocortical tract with cell organic structures in the ventral tegmentum of the mesencephalon which undertakings to the amygdaloid nucleus, nucleus accumben, hippocampus, frontal cingulate and entorhinal composite ( Horton, Schizophrenia, 2011, p. 3 ) ( Kathryn L. McCance A ; subdivision editors, 2010 ) . The grounds is supported by looking at the consequence of pep pill in let go ofing Dopastat from dopaine receptors [ subtyped D1, D2, D3, D4 and D5 ] in the encephalon taking to schizophrenic like symptoms ( Horton, Schizophrenia, 2011, p. 3 ) . However, grounds against based on looking at the CSF concentration of HVA found non to be elevated as expected, no alteration in DA receptors in PET scans of drug-free schizophrenics but studies show that increased Numberss of D2 receptors in station mortem sample were due to drug intervention ( Horton, Schizophrenia, 2011, p. 3 ) . In decision, it is hypothesized that hypodopaminergicA transmittal in the dorsal prefrontal cerebral mantle leads to veto symptoms whilstA hyperdopaminergicA transmittal in theA mesolimbicA tracts such as the temporal lobe, A hippocampal, A Amygdala, nucleusA accumbensA and anterior cingulated cerebral mantle leads to positive symptomsA ( Kathryn L. McCance, 2010 ) .A A Glutamate: Evidences indicate an under activity of glutamate transmittal such as reduced cerebrospinal fluid [ CSF ] glutamate, loss of glutamate nerve cells in median temporal parts, addition in certain types of glutamate receptors to counterbalance for lessening in transmittal, glutamate receptor subtype [ NMDA ] antagonist PCP makes schizophrenic symptoms worse ( Horton, Schizophrenia, 2011, p. 3 ) GABA [ gamma-aminobutyric acid ] : Evidence of decreased GABA transmittal due to dorsal prefrontal cerebral mantle alterations/ hypoactivity such as lessened maps ofA GlutamicA acidA DecarboxylaseA needed in biogenesis of GABA lead to the negative symptomsA ( Kathryn L. McCance, 2010 ) .A 5HT [ 5-hydroxytryptamine ] : Evidence show an addition in 5HT [ 5-hydroxytryptamine ] transmittal ( Horton, Schizophrenia, 2011, p. 4 ) . A Environmental FACTORS: These include malnutrition in gestation, grippe in 1st trimester, winter/spring births, bringing complications, caput perimeter at birth and minor physical changes ( Horton, Schizophrenia, 2011, p. 5 ) TREATMENTSA Antipsychotic drugs besides calledA Major tranquilizers to clasp the nerve cell which are effectual in handling acute psychosis and cut downing the hazard of future psychotic episodes ( MedicineNet, 2011 ) .A OlanzapineA andA AripiprazoleA are both 2ndA coevals atypicalA antipsychoticsA which exert their effects on a scope of neurotransmitter receptors i.e. non selective compared to typical 1st coevals neuroleptic which chiefly block D2 receptors. There is a discriminatory action on the DA mesolimbic/mesocortical tract over a nigro-stratial tract but research in carnal surveies is ill-defined ( Horton, Major Tranquillizers, 2011, p. 4 ) . Atypical major tranquilizers which have comparatively high 5HT2A adhering affinity to D2 receptors produce lower EPS [ exptrapyramidial symptoms and depress negative symptoms. Upon entry into the synaptic infinite, the antipsychotic drug must vie with endogenous Dopastat for the receptor. Therefore, curative concentration needed to barricade 50 % o f Dopastat receptors in the presence of dopaminewill be higher than that needed in its absence ( Philip Seeman, 2004 ) . This falls in conformity with the equation C50 % = Ki A? [ 1+D/D2 high ] , where D is the dopamine concentration in the synaptic infinite whilst D2 high is the dissociation invariable of Dopastat at the high-affinity province of the Dopastat D2 receptor ( Philip Seeman, 2004 ) . ARIPRIPAZOLEA Indication: Relieve positive symptoms related to extra Dopastat and negative symptoms towardsA dopaminergicA hypofunction.A It is given at a day-to-day dose scope of 10-30mg but get downing dosage could be 10 to 15mg per twenty-four hours ( Kaplan, 2008 ) .A Mechanism: A AripiprazoleA is aA quinolinoneA derivative. Partial agonist at Dopastat D2 and 5-HT1A receptors upon entry into the synaptic infinite and as an adversary competes with the endogenous serotoninA at 5-HT2 receptors. Described as a Dopastat system stabilizer, in high degrees of Dopastat will move as an adversary ( Horton, Major Tranquillizers, 2011, p. 5 ) such as the mesolimbic tract but non in parts with normal Dopastat degrees such as nigrostratial and tuberoinfundibular tracts. Therefore, a D2 partial agonist is expected to cut down the positive symptoms of schizophrenic disorder without bring forthing motion upsets or elevated lactogenic hormone degrees. In countries where Dopastat activity is low, will move as an agonist to let go of dopamine nerve cells from suppression. The D2 receptor is coupled to inhibitory G-proteins [ Gi ] , which upon agonist binding, dissociates from the receptor to suppress secondary messengerA signallingA mechanisms taking to farther suppr essions. At 5HT1A receptors, aripiprazole besides acts as a partial agonist, hypothesized to correlate with overall efficaciousness against the symptoms of schizophrenic disorder including depression, anxiousness and negative symptoms ( MJ. , 2000 ) .The counter consequence on 5HT2 receptors are believed to be associated with a low liability for extrapyramidial side effects [ EPS ] and good for alleviating negative symptoms by disinhibiting the Dopastat system in the striate body and prefrontal cerebral mantle ( Horton, Major Tranquillizers, 2011, p. 4 ) . Normally, DA nerve cells in the nigrostriatum and prefrontal cerebral mantle are inhibited by serotonin heteroreceptors but hostility of 5HT2 receptors means the release of Dopastat neurones, lower D2 receptor obstruction. It besides does non bring on weight addition or QT protraction ( Horton, Major Tranquillizers, 2011, p. 5 ) . Pharmacokinetics: High soaking up making peak plasma concentrations after 3 to 5 hours, protein binding is 99 % and its half life is approximately 31 to 146 hours doing it suited for one time day-to-day dosing, clearance is affected by age cut downing greatly in the aged. It is extensively metabolised by Cytochrome P450 3A4 and 2D6 enzymes with active metabolite, dehydroaripiprazole ( Burns, 2004 ) . Side EFFECTS: orthostatic hypotension, increased hazard of ictuss, sedation OLANZAPINEhttp: //www.druglib.com/img/Rx/3232.gif ( Druglib, Zyprex ( Olanzapine ) -Description and Clinical Pharmacology, 2006 ) Indication: A negative and positive symptoms ofA schizophrenia, A acute passion with bipolar upset, agitation and psychotic symptoms in dementedness. It is given at a day-to-day dose scope of 5-20mg ( Burns, 2004 ) . Class of drug: Atypical psychotics, ATC Therapeutic CategoryA N05AH: Diazepines, A oxazepinesA andA thiazepines ( PharmGkB, 2010-2011 ) A A Mechanism: Adversary enters the synaptic infinite and competes with the endogenousA ligandsA to suppress IÂ ±-1 adrenoceptors and 5-HT2C which both mediates their actions by association with G proteins [ Gq/11 ] that activate a phosphatidylinositol- Ca 2nd courier system whilst at 5-HT2A promotes dopamine release ( Druglib, 2007 ) . In the nigrostriatal tract increased DA reduces EPS and tardive dyskinesia ( Yogesh Dwivedi, 2005 ) but in the mesocortical tract, increased DA release may better negative symptoms, that neuroleptic induced shortage syndrome ( Voruganti L, 2004 ) . OlanzapineA does non look to barricade Dopastat within theA tubero-infundibularA piece of land, explicating the lower incidence ofA hyperprolactinemiaA than with typical antipsychotic agents but alternatively blocks 5-HT2A receptors ( Druglib, 2007 ) . As an adversary of D1 Gs-coupled proteins receptor it prevents activation of Adenylyl cyclase and DARPP-32 ( dopamine andA cAMPA regulatedA phosphoproteinA of 32A kD ) .A Dopamine adhering activates the 2nd messengerA camp to trip ProteinA KinaseA A ( PKA ) which phosphorylatesA DARPP proteins atA ThreonineA residue 34A to suppress phosphataseA protein ( PP1 ) leting PKA to hold a longer active life and overall, A enhanceA the nerve cell s sensitiveness to dopamine signalling. In contrast, dopamine adhering to D2 receptors has an opposite consequence: the 2nd messengerA phosphorylatesA DARPPA on Thr75, doing it to move as a proteinA kinaseA inhibitor andA decrease the nerve cell s sensitiveness to signalling. The D2 and D4 receptor are coupled to inhibitory G-proteins, which dissociate from the receptor on agonist binding and inhibit secondary messengerA signallingA mechanisms doing farther signalling suppression ( Greengard, 2011 ) . Antagonist adhering inhibits this procedure, ensu ing in cell depolarisation.A They besides cause Dopastat to cut down DARPP-32A phosphorylation ( Sarah M. Clinton, 2005 ) . A In add-on, it antagonises histamine H1, A MuscarinicA M1 [ mediate their actions through G-protein-Gq/11 [ in some cases Gs and Gi ] .A Therefore, olanzapine can be seen to hold multiple receptors activities. Side EFFECTS: CNS depression which is due to it counter effects on H1 receptors, orthostatic hypotension, automatic tachycardia and rhinal congestion due to alpha1 suppression whilst blurred vision and urine keeping due to M1 suppression, weight addition, increased QT intervals observed in ECG and increased hazard of shot in dementia aged patients ( Horton, Major Tranquillizers, 2011, p. 4 ) Pharmacokinetics: its half life is 20-70 hours, plasma clearance is 12 to 47L/h and its protein binding is 93 % . It is eliminated extensively by first base on balls metamorphosis, with about 40 % of the dose metabolized before making the systemic circulation by enzymes ; Cytochrome P450 2D6 and 1A2 with no active metabolite ( Burns, 2004 ) . Decision Olanzapine and aripiprazole are therapeutically used orally to handle schizophrenic disorder and have different mechanisms of action. Olanzapine is a multireceptor adversary, suppressing M1, H1, IÂ ±-1, D1, D2, D4 and 5-HT2A/2C receptors whilst Aripiprazole is a breakthrough neuroleptic with partial agonist activity on 5-HT1A and D2 receptors leting it to jump its actions and an adversary of 5-HT2 receptors. They are both used to alleviate positive and negative psychotic symptoms presented in schizophrenic disorder and both have a comparatively high 5HT2A adhering affinity to D2 receptors produce lower EPS [ exptrapyramidial symptoms ] and depress negative symptoms. More so, they portion side effects such as orthostatic hypotension, . Therefore, close monitoring of patients is necessary to guarantee they acquire the best out of their interventions with control over their symptoms and possible drug induced side effects. NICE guidelines published 2002, it is recommended that unwritte n untypical antipsychotic drus are considered in the pick of first-line interventions for persons with freshly diagnosed schizophrenic disorder or considered as intervention options for single presently having classical antipsychotic drugs who, despite equal symptom control, are sing unacceptable side effects and for those in backsliding who have been antecedently experienced unsatisfactory direction or unacceptable side effects ( Horton, 2011 ) . hypertext transfer protocol: //books.google.co.uk/books? id=ubG51n2NgfwC A ; pg=PA546 A ; lpg=PA546 A ; dq=aripiprazole+schizophrenia+mechanism A ; source=bl A ; ots=tm_B5jFcxW A ; sig=KkMB7rniRAyPMTbXjK3CQl8xXPA A ; hl=en A ; ei=gfKUTYCoMIeohAfL6rT2CA A ; sa=X A ; oi=book_result A ; ct=result A ; resnum=9 A ; ved=0CFoQ6AEwCDgK # v=onepage A ; q=aripiprazole % 20schizophrenia % 20mechanism A ; f=false hypertext transfer protocol: //books.google.co.uk/books? id=WuA4LsWXXWEC A ; pg=PA510 A ; lpg=PA510 A ; dq=olanzapine+inhibition+of+5HT2+receptors A ; source=bl A ; ots=ijCtcFYFJk A ; sig=IdYjVggzCLVrGihyl435NUPEjKs A ; hl=en A ; ei=3uqZTcjlO9G5hAesy53wCA A ; sa=X A ; oi=book_result A ; ct=result A ; resnum=5 A ; ved=0CCsQ6AEwBDgK # v=onepage A ; q A ; f=false

Globalization Impact on Life Career and Future

Globalization Impact on Life Career and Future Introduction Globalization is the international unification, global amalgamation of individual national economies, social cultures, technologies, and political powers into an integrated single society. Globalization is not a recent day concept and has taken many years for the current world to develop into what it is today.Advertising We will write a custom report sample on Globalization Impact on Life Career and Future specifically for you for only $16.05 $11/page Learn More Globalization has transformed the world outlook into a more open-minded or neo-liberal present day form. Globalization can also be viewed as the process of heightening relationships between national economies through improved international trade, foreign direct investments by Multinational corporations, and international financial investments. The world in the recent past has witnessed fast flow of information, people and materials from one part of the globe to the other, thanks to globa lization. Globalization in the most basic terms can be viewed as the integration of the global cultures, and as a result reducing the world into a global village. Growing integration of the world economies and societies has been an endless and heated debate in the global economies in the recent past. In the 21st century, great leaps in the technological advancements coupled with myriad innovations have been witnessed. As such, integration of societies has become possible as people can communicate with much ease from one part of the world to another. Globalization can be characterized be expansion of communication networks and transportation systems. For instance, the internet has made it possible to relay data and information from one part of the world to the other more promptly hence crating a global network. Also, transportation of material and information has been improved through the innovation of more efficient transportation of networks. For example, the innovation of large an d fast air couriers and electric trains has enhanced movement of people from one nation to the other. Hence, it is possible to travel half way the world within one day thanks to improved transportation. Globalization as a result, has seen the world become a global village with different economies, societies and cultures creating a global network. Globalization, as a matter of fact, has improved the wellbeing of the global citizens. Individuals and firms can outsource labour, materials and funding they require form any part of the world with much ease thanks to globalization. It is becoming apparent that no nation or individual that wants to compete reasonably can dispense with dynamics of globalization and survive in the current global market.Advertising Looking for report on business economics? Let's see if we can help you! Get your first paper with 15% OFF Learn More Globalization offers many opportunities to the global citizens among them making their liv es better. However, there are a couple of risks and challenges associated with globalization and that have a bearing in the lives of the global citizens. This essay seeks to analyze three key areas that could Impact one’s life career and future. The opportunity of Poverty reduction Globalization has increased the flow of fund and information globally through online stock markets. Global financial markets where different national economies can access funds have been made possible by globalization. Nations can access external borrowings and also trade in national currencies hence helping support trade and investments levels. Nations can use the funds accessed to develop the infrastructures and create employment to their citizens hence improved well being. Globalization has also widened the global market for products and services hence impacting on the global industries. Mobility of the factors of production has become possible through globalization. Nations that are not endowed with natural resources can now access these resources through importation and also enjoy the vast global market hence reducing poverty and facilitating international trade. Moreover, globalization has supported the notion of free trade through lowering trade restrictions on direct foreign investments between nations. This has also enabled foreign companies to be located in different nations where they are close to the raw materials and hence creating employment in those countries. Scenario 1 A third world national government can attract foreign citizens’ investments through offering governments securities for sale in the security exchange market. For instance, the government of Kenya encourages foreigners from developed nations to invest in government bonds by reducing regulations and the tax rates on interests on the investments. In this way, the government attracts foreign investments and hence is able to access funds for development of say infrastructure. The risk of incr easing inequality among the rich and poor nations Inequality can be defined as the disparity between the incomes and the standards of living among countries their citizens. Various globalization aspects could contribute to the widening of the poverty gap between nations.Advertising We will write a custom report sample on Globalization Impact on Life Career and Future specifically for you for only $16.05 $11/page Learn More For instance, the world wealthy nations utilize the loopholes in the liberal markets to start Multinational Corporations (MNCs) in the developing nations. These MNCs utilize the local resources, utilize cheap labor from the local citizens and repatriate the gains made to their wealthy nations. As such, the poverty gap continues to grow between the rich and the poor nations. Scenario 2 Developed nations’ MNCs such as the Barclays bank invest heavily in third world countries to their mother nations’ benefit. For instance, the Barclays bank has invested in Kenya (Africa) where it reaps a lot of profits, occasionally much than in their country of origin. The bank offers poor salaries to the local citizens and repatriates the rest of the profits to the United Kingdom contributing to the widening of the poverty gap. The risk of increased international overdependence Globalization has made it possible that nations can specialize in what they can produce more effectively and with much efficiency. Naturally endowed nations supply the natural resources to the less endowed nations. Global outsourcing in regard to the factors of production has become apparent. As such, nation can outsource expertise from more developed nation to suffice their labour needs thus eliminating the need for incurring expansive training of nationals. However, the international interdependence exposes nations to the risk of becoming over dependent and failure to develop capacity internally. Increased international overdependence is multif aceted and could range from production of physical good to the rendering of services. Less developed nations could import technology to spur their own development but sometimes it becomes very expensive when compared to developing own technology. Scenario 3 Most countries in the third world cannot have import expertise from the developed world. For instance, China and Japan have continued to dominate the infrastructure development contracts in Africa. Most road construction tenders in Kenya are won by the Chinese. Hiring of expertise is an expensive affair and developing nations such as Kenya should concentrate on their own expertise. Response plan for high priority risk/opportunities associated with key areas stated In response to the opportunity of poverty reduction, nations should optimize their gains reaped from globalization. For instance, nations should enter into trade agreements that enable them to access raw materials cheaply and also enjoy the expanded market. The nations can also improve their transport and communication networks to enhance the flow of information and materials. In order to mitigate the effects of widening the poverty gap among the rich and poor nation, international bodies should come up with measures such as trade conventions that regulate the conduct of the rich nations. The developing nations should also formulate legislation that regulate the conduct of foreign companies such as imposing higher taxes and imposing demands to such companies to offer better working conditions for the locals.Advertising Looking for report on business economics? Let's see if we can help you! Get your first paper with 15% OFF Learn More Summary report This essay has analyzed the way globalization as a megatrend has the potential of affecting ones life, career and opportunities. Globalization has continued to spark debate in economic world as different people interrogate its effects on the global economic spectrum. It has influenced the way information and factors of production flow in the globe reducing the world into a global village. Among the opportunities offered by globalization is the education of poverty through improvement of standards of living. Conversely, the risks associated with globalization are the widening of the poverty gap among the poor and the rich nations, and increased international overdependence. To ramify on the opportunities, nations should maximize their participation in international trade through the development of infrastructure. On the other hand, the risks should be combated through trade regulations that curtail the conduct of the rich nations and encouraging the development of nati ons own internal capacity to eliminate over dependence. Nations can regulate the various dynamics of globalization and benefit positively from the many opportunities it offers to global citizens. References Goyal, K. A. (2006). Impact of Globalization on Developing Countries (With Special Reference To India). International Research Journa l of Finance and Economics , pp 1-20. Goyal, K. A., Khicha, P. K. (2010). â€Å"Globalization of Business: Future Challenges†, Third concept. An International Journal of Ideas. , p 13. Lucas, S. M. (2007). Critical essay: Does Globalization cause Inequity Among Rich and Poor Nations? Global economics , pp 3-4. Obioha, P. U. (2010). Globalization and the future of African culture. Philosophical Papers and Reviews , pp 1-8. Ocampo, J. A. (2010). Rethinking Global Economic and social Governance. Journal of Globalization and Development , p 27. Schumkler, S. L. (2004). Benefits and risks of Financial Globalization: Challenges for Developing Cou ntries. Journal of Development Research , p 26. Stevens, W. (2007). The risks and opportunities from Globalization. Newzealand Treasury , pp 14-16

Term paper Example | Topics and Well Written Essays - 1500 words

Term Paper Example It is further concerned with other activities such as the disposition of offenders and treatment of juveniles found to have committed a criminal act. The criminal justice system also includes public institutions and key players such as the police, prosecutors, courts, corrections, crime victims and so on (â€Å"Criminal Justice System†). Purpose According to Frase and Weidner, the criminal justice system has the primary purpose of enforcing laws in line with the defined rules and limitations. The authors furthered that the â€Å"system† refers to â€Å"something highly rational – carefully planned, coordinated, and regulated† (Frase & Weidner). On the other hand, Drakeford and Friedman reiterated that controlling crime and assuring due process are the two main purposes of the criminal justice system (5). Key Players’ Functions The criminal justice system is composed of four institutions, namely, police, prosecution, courts, and corrections, and thes e interact with each other towards a balanced action for justice. In simpler terms, the police are responsible for enforcing the law; the courts are responsible for hearing the legality of the crime, and; corrections house the convicted offenders. The following section lists the specific responsibilities of these key players. Police. According to Stevens, the police have intended and unintended functions that include the following: morals enforcement, class control, riot control, order maintenance, safety, service, and crime fighting. Other specific functions include the following: To subdue conduct that is considered threatening. To protect or help a person who is harmed. To uphold security in the community. To help people who are unable to help themselves such as the handicap, the mentally ill, the old and the young, and others. To help in resolving conflict between groups and individuals. To oversee the movement of vehicles and people. To recognize problems that can become seriou s problems (Stevens). Prosecutor. The main function of the prosecutor in a trial is to convince the jury that the defendant is guilty of the crime. Other functions include, but not limited to, the following: To ensure that the guilty person is convicted. To charge suspect with a crime. To represent the government during a trial. To assist in selecting jurors. To call on witnesses to prove the defendant’s guilt. To cross-examine the witnesses presented by the defense (Read). Court. The court consists of the prosecutors, judges and other stakeholders, each of which has roles to fulfill. The prosecuting office must present evidence to the court regarding the guilt of the offender. The prosecutor is usually involved during the initial investigation, pretrial hearings and during the trial. During the preliminary hearing, several factors such as the severity of the offense, will determine the next step. The lack of probable cause can lead to the dismissal of the case. Otherwise the case may be brought to the grand jury. If there is sufficient evidence, the grand jury then decides to try the offender (Drakeford & Friedman, 8-9). Corrections. Drakeford and Friedman stated that corrections have several purposes, one of which is to punish the offenders. This is based on the belief that punishment deters offenders from criminal behavior. Another purpose of the corrections is to protect the society from these offenders. The third purpose is to rehabilitate the offenders (10). Interaction of Key Players The key players in the criminal justice system,

Life is beautiful Essay Example | Topics and Well Written Essays - 250 words

Life is beautiful - Essay Example The belief that the world is beautiful is created by Guido for his son. In response, Giosue does not understand the real situation even unto death. The purpose of the two beliefs in the film is to develop the plot of the film. Without the Giosue belief of a better world, the depiction of the holocaust cannot be illustrated and developed. The different perception of life by Giosue helped develop the plot. It is Guido’s belief that the world may change, but the perception of the human race cannot be hidden even when conducting business. Being a Jew, Guido presents himself as a caring father, but has racism in the way the family business is operated (Benigni). The concentration camp in the main set up of the film. It is based on the execution of the Jews, but Guido ensures that the sons belief in a beautiful world with no problems. The creation of a different view of the world helps in twofold view creation. In conclusion, the film has developed the two fold view by looking at the father and son approach to the world. The beautiful world is created in the son’s view while the real world is depicted in the life

Diffusion and Osmosis Through Dialysis tubing Essay Example for Free

Diffusion and Osmosis Through Dialysis tubing Essay We did this experiment to test the diffusion of different substances through dialysis tubing. We used what we knew about diffusion to make predictions on what we thought the mass of the dialysis tubing to be after submerging them for 30 mins and we knew that diffuse occurs from highest concentration to lowest concentration. Since the dialysis tubings are filled with different substances than what they are being put into then they should all gain or lose mass. If the dialysis tubing is submerged in different substance than what is in the tubing then some of the dialysis tubings will lose mass and some will gain mass. To begin this experiment we filled 5 dialysis tubings with one of the five substances: water, egg white, NaCl, glucose, or sucrose. The equipment used was: 5 dialysis tubing, a scale, bekers, water, egg white, sucrose, glucose, NaCl, and 5 cups. We put the five dialysis tubing filled with one of the five substance into a cup filled with one of the substance: water, egg white, NaCl, glucose, or sucrose. Then we let them sit in there for 30 mins then took them out of the cups and remassed them. The dialysis tubing did let some of the different solutions in but not all of them. Most of the dialysis tubing gained mass and some lost some mass as well. We found that the substances go from an area of high concentration to an area of low concentration. The data supports our purpose of doing this experiment to find out what happens when a substance in a dialysis tubing is put into a cup of a difference substance to see which ones gain mass and which ones lose mass. A pattern of the data is that the control group did not gain or lose mass. Two of the substances gained mass and two of the substance lost mass. Our results proved our hypothesis that some of the dialysis tubings would gain mass and some of the dialysis tubing would lose mass. Because two of the dialysis tubings gained mass and two of the dialysis tubings lose mass it just shows that the substances went for an area of high concentration to an area of low concentration. A few errors of our experiment is that we could have not used enough of the substances in the dialysis tubings or we could have left the dialysis tubings the cups of substance for a long amount of time which could have changed our results majorly because the more time the dialysis tubings sit in the cup of substances the more they had time to diffuse. Osmosis through Dialysis Tubes We performed this experiment to see how water moves across a semi-permeable membrane. We filled the dialysis tubes with different Mole concentrations of sucrose, and we used our knowledge of osmosis to figure out the different concentrations. If the dialysis tube increases both in size and weight, then that dialysis tube had the highest mole concentration of sucrose. We learned that during osmosis, a form of passive diffusion which means that it requires no energy to move across the membrane, water will always move to the area where the water concentration is lower, so if the sucrose has a high mole concentration then the water will move into the bag since there is less water there, and if the bag has a low mole concentration then there will be little water moving into the bag since there is already a relatively high concentration in the bag. The materials we used to conduct this experiment were: 6 Dialysis Tubes, 6 different mole concentrations of sucrose (0 M concentration, 2 x 10⠁ »Ã‚ ¹M concentration, 4 x 10⠁ »Ã‚ ¹ M concentration, 6 x 10⠁ »Ã‚ ¹ M concentration, 8 x 10⠁ »Ã‚ ¹ M concentration, 1 M concentration), 6 cups to hold the water, a scale to weigh the mass of the dialysis tubes before submerging the bags in water and after. To begin this experiment we first filled the bags with the different mole concentrations of sucrose, the different concentrations were color-coordinated with different colors for a different concentration. Next we weighed the mass of the bags before submerging them in the water, and filled the cups with water so that we could submerge the tubes. After the bags were massed and the cups were filled with water we submerged the bags for 30 minutes. After the 30 minutes were up we took the bags out of the water and blotted them off with a dry paper towel. Finally we massed the bags and recorded our results so that we could compare them with the results from before we submerged the tubes. After analyzing our results we concluded that the Blue substance was water, because it gained no mass, The purple substance was the 2 x 10⠁ »Ã‚ ¹ M concentration because it gained little mass, more than the blue substance. The light green substance the 4 x 10⠁ »Ã‚ ¹ M concentration because it gained some mass, more than the 2 x 10⠁ »Ã‚ ¹ .concentration but not as much as the 6 x 10⠁ »Ã‚ ¹ M concentration. The red substance was the 6 x 10⠁ »Ã‚ ¹ M concentration because it gained more mass than the 4 x 10⠁ »Ã‚ ¹ M concentration but less than the 8 x 10⠁ »Ã‚ ¹ M concentration. The green substance was the 8 x 10⠁ »Ã‚ ¹ M concentration because it gained more mass than the .6 Molar concentration but less than the 1 M concentration, and finally the Yellow substance was the 1 M concentration, because it gained the most mass. Our results answered our question, How can you tell the molar concentration of a 0 .2, .4, .6, .8 , and 1 molar concentration of sucrose? Our results showed us that our hypothesis, If the dialysis tube increases both in size and weight, then that dialysis tube had the highest mole concentration of sucrose, was also correct because the Yellow substance gained the most mass out of all the other substances and was also the substance with the highest Molar concentration of 1, and the Blue concentration gained no mass therefore it was water, because if there is as much water on the inside as the outside then no osmosis takes place. Some sources of error for this experiment is that we could have left the solutions in longer, possibly changing our results. Or that we could have also not used enough of the solutions. Diffusion using Potato rounds We are conducting this experiment in order to see what happens during the process known as diffusion across a semi-permeable membrane. Our hypothesis was that if the Molar concentration is higher in a sucrose solution then the potato will lose mass and if the Molar concentration is lower in a sucrose solution then the potato will gain mass. We learned about diffusion and how a semi-permeable membrane only lets certain molecules pass through it. Diffusion is the act of a molecule passively passing through a semi-permeable membrane. This action of diffusion helps regulate the cell’s processes and this is done on a regular basis so that the cell can live and function. For this experiment we needed: 36 potato sticks (18 of a sweet potato and 18 of a regular potato), 6 sucrose solutions (0M, .2M, .4M, .6M, .8M, and 1M), a scale, cups. First what we did was we massed our potato sticks, and recorded them. Next we filled the cups with the different solutions of sucrose and submerged the potato sticks for 30 minutes. After the 30 minutes we massed the potato sticks and recorded the changes and analyzed the previous data with the data we received, here are our results: After analyzing our results, we concluded that the potato sticks in the Blue concentration gained the most mass out of all the solutions, and the yellow concentration grained not mass, but instead lost mass. This is because water will move from an area of high concentration to an area of low concentration. We also calculated the water potential of the potato sticks and found it to be -7.86 for a regular potato and -17.01 for the sweet potato. All of the experiments that we did, the substances had a semi-permeable membrane that only let certain things through it. All of the experiments consisted of putting different substances into cups filled with different solution and seeing if they lost or gained mass dependent on if the amount of water that was in the substances and the solutions. There was a pattern throughout all of the experiments where one of the substances in the cups of solution gained nor lost mass but stayed the same and two of the substances in the cups of solution gained mass and two of the substances in the cups of solution lost mass.

Comparing Marriage in Eveline and The Bride Comes to Yellow Sky :: comparison compare contrast essays

Comparing Marriage in Eveline and The Bride Comes to Yellow Sky  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   At times, a marriage may be motivated by feelings other than romantic love. Themes of alternative motivations for marriage are explored in the literary works, "Eveline" and "The Bride Comes to Yellow Sky". Also, in each of these stories, the decisions of a principle character is greatly influenced, by the opinions of others concerning marriage.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Sometimes people do not marry to be with one that they love, instead, they marry to flee a place or a person that they dislike. At the age of nineteen, Eveline consented to marry Frank to get away from her job at the Stores and her father.   She thought her comrades at the Stores might call her a fool to run off with Frank to get married and that Miss Gavan would be glad she was gone.   Although she feared her father would become violent because of her marriage, she knew some others would respect her. She planned to explore a new life with Frank in his distant country home, Buenos Aires.   Frank seemed older than Eveline from the stories he had told of his experiences.   Eveline was acting upon impulse to escape.   The more experienced Frank "would save her.   He would give her life, perhaps love, too."   (Joyce 331).   Her mothers life of commonplace sacrifices closing in final craziness (Joyce 331) was reason enough for Evelines sudden need to marry Frank.     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Eveline weighed questions of her decision up to the last minute.   She struggled with her feelings toward her known life.   As the time for her to leave with Frank approached, she realized that her current life was not all that bad.   Marriage would not be the answer to her dilemma.   She did not go with Frank.  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     The people of Yellow Sky knew Sheriff Jack Potter had gone to San Antonio, but did not know why he went nor when he was coming back.   However, Potter had gone "to meet a girl he believed he loved, and there, after the usual prayers, had actually induced her to marry him, without consulting Yellow Sky for any part of the transaction."   (Crane 212).   Potter and his bride were older than the average newly weds during that time period.   They were self conscious because people in the parlor-car stared at them.   Potter began to feel a greater self consciousness about how his town of Yellow Sky would respond to his marriage.

Lady Macbeths Character Analysis

Lady Macbeths Character At the beginning of the play Lady Macbeth is very eager on taking the throne and would do anything in order to get it, even. She is also very controlling over her husband and demanding. We first see Lady Macbeth in the play when she is reading a letter from macbeth who is explaining what his future holds from him according to the three witches, which is that he will take on the throne. Lady Macbeth already is very ambitious about this and starts to plan to kill King Duncan. She says ‚‘‘ Hie thee hither,That I may pour my spirits in thine ear;‘‘ This suggests that she is controlling and whatever she tells Macbeth she will easily persuade and control him to kill king Duncan. Lady macbeth is suggesting that her maternal instincts and her nurturing nature is stopping her from killing King Duncan. She says ‚‘‘ Unsex me here and full me from the crown to the toe, come to my woman breasts and take my milk for gall‘‘. This suggests shes wanting to get rid of her feminity, so she can actually be evil without feeling guilty and that take her milk which she would used to care for her child into poison. She then struggles to overcome her feminity and makes Macbeth kill King Duncan. She then sees the throne in sight and is extremely happy about this but Macbeth’s conscience fights with him making him feel guilty and regret what he has done. The Blood is a